Evaluation of Circulatory Concentration of Cytokines PDGF-BB, TGF-β1, and IL-10 in Canine Generalized Demodicosis

Mayank Parwari, G C Mandali, Jignasha M Parmar, R A Mathakiya

Abstract


The purpose of this study was to investigate the changes in circulating concentrations of platelet-derived growth factor-BB (PDGF-BB), transforming growth factor beta-1 (TGF-β1) and interleukin-10 (IL-10) in dogs with generalized demodicosis. Twelve dogs with generalized demodicosis were diagnosed based on clinical findings and microscopic examination of the cutaneous scrapings. Six healthy dogs were included in the study as a control. Commercial specific ELISA assays measured circulating concentrations of plasma PDGF-BB, and serum TGF-β1 and IL-10. Marked and significant increase in plasma PDGF-BB and serum TGF-β1 concentrations was evidenced in diseased dogs, while increase in serum IL-10 concentration was non-significant. The levels of all three markers dropped down to near normal/healthy status after the treatment of diseased dogs. These results indicate that the increased concentrations of circulating PDGF-BB, TGF-β1, and IL-10 play a pivotal role in the pathogenesis of the canine demodicosis.

Keywords


Dog, ELISA assay, Generalized demodicosis, IL-10, PDGF-BB, TGF-β1, Immunosuppression.

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DOI: https://doi.org/10.21887/ijvsbt.15.2.16

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